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+ Preclinical work examines its role in cellular repair processes , metabolic efficiency, and stress-response signaling

One lesser-known side effect is lip darkening, also known as hyperpigmentation

Hosny et al

In turn, macrophage-derived IL-6 activates STAT3 signaling in CRC cells, facilitating c-Myc transcription and transforming macrophages into a pro-tumor M2-like phenotype, which promotes tumorigenesis